Preserving Single-Cell TranscriptomicSignals of Mitochondrial Dysfunction inCutaneous...
This whitepaper explores how conventional mitochondrial filtering in single-cell RNA sequencing may remove biologically meaningful signals in cutaneous lupus erythematosus. Using a preliminary comparison of lesional, non-lesional, and healthy skin, it highlights mitochondrial Complex I signals associated with disease and discusses adaptive filtering and pathway annotation approaches for preserving mitochondrial biology in autoimmune research.
