About ThinkBio.Ai
ThinkBio.Ai is revolutionizing the biopharmaceutical and healthcare fields with AI-powered resources. Our five specialized teams—clinical, science, AI, software, and managed services—work together to develop AI-based solutions that are deployed horizontally (data platforms and workflow tools) and vertically (clinical focus areas such as oncology, autoimmune diseases, and cardiology). Our mission is to help our clients find answers to their toughest questions and to accelerate the application of scientific breakthroughs in the clinic.
Position Summary:
We are seeking a highly motivated individual with expertise in structural biology to join our team as a Postdoctoral Fellow or Scientist, depending on experience level. The position will involve applying structural biology techniques to understand protein-protein interactions, drug-target binding, and disease mechanisms, integrating these insights into computational models. The successful candidate will have a PhD in structural biology, biophysics, biochemistry, or a related field, with a deep understanding of macromolecular structure and function. Fresh PhD graduates will be hired as Postdoctoral Fellows for a two-year term, while candidates with at least two years of postdoctoral fellowship or industry experience will be considered for a Scientist position.
Key Responsibilities:
- Apply deep domain knowledge in structural biology to characterize macromolecular complexes and understand their roles in disease pathways.
- Integrate structural insights with multi-omics data (genomics, transcriptomics, proteomics, and metabolomics) to understand molecular mechanisms of disease.
- Utilize and develop computational tools for structural modeling, molecular dynamics simulations, and ligand docking to complement experimental data.
- Stay up to date with the latest advancements in structural biology, biophysics, and computational methods to incorporate cutting-edge research into disease modeling efforts.
Collaboration & Project Management:
- Work closely with cross-functional teams, including disease domain experts, computational scientists, and clinicians to enhance translational research efforts.
- Work with the Scientific Manager to help in project planning, execution, and reporting, ensuring alignment with research objectives.
- Communicate findings effectively through reports, presentations, and discussions with internal teams and external collaborators.
- Publish research findings in high-impact, peer-reviewed journals.
- Present work at scientific conferences, symposia, and internal research meetings.
- Contribute to grant applications and funding proposals where relevant.
Qualifications & Experience:
- PhD in structural biology, biophysics, biochemistry, or a closely related field.
- Strong expertise in at least one major structural biology technique (e.g., X-ray crystallography, cryo-electron microscopy (cryo-EM), NMR spectroscopy).
- Solid understanding of protein structure-function relationships, macromolecular interactions, and their relevance to disease biology.
- Experience in experimental design, data collection, data processing, and structure determination.
- Excellent verbal and written communication skills, with the ability to convey complex structural biology concepts clearly.
Preferred:
- Experience with computational structural biology tools (e.g., Rosetta, AlphaFold, molecular dynamics software).
- Previous experience working in a multidisciplinary research environment.
- Familiarity with AI/ML approaches in structural biology or drug discovery.
Other Considerations:
- Fresh PhD graduates will be hired as Postdoctoral Fellows for a two-year term with an opportunity for promotion to Scientist based on performance.
- Candidates with at least two years of postdoctoral experience in structural biology in either academia or industry will be hired as Scientists with opportunities for career advancement.
Why Join Us?
- Work at the cutting edge of structural biology and disease research.
- Contribute to groundbreaking disease modeling and molecular insights.
- Collaborate with leading experts in multiple disease domains.
- Competitive salary, benefits, and career development opportunities.
Application Instructions:
Interested candidates should submit a cover letter and CV to careers@thinkbioai.com.